Biophotonics, the application of photonics technology to biological imaging and sensing, is currently experiencing rapid development in modern technology. Advances in nanotechnology have allowed new modalities of optical imaging and sensing with readily accessible approaches. New imaging methodologies with advanced optical system design and computational methods enable more powerful imaging technologies such as super-resolution, nonlinear, Raman, photoacoustic, OCT, and phase quantitative imaging. Advances in nanoprobes, including near infrared probes and plasmonic nanoparticles, enable functional sensing and empower the existing imaging technology. Miniaturized fiber optic imaging developments hold great potential for noninvasive disease diagnosis in clinics. This session fosters interdisciplinary collaboration by bringing together engineers with backgrounds in optics and mechanics alongside chemists, biologists, and clinicians in a unified setting.